Which histologic findings are characteristic of esophageal motility disorders?

Updated: Dec 29, 2017
  • Author: Eric A Gaumnitz, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Endoscopic biopsy results of the mucosa and submucosa are generally normal. The depth of a standard endoscopic biopsy is not usually deep enough to reach the myenteric nerves. Histologic findings from surgical and necropsy examinations of the smooth muscle esophagus in patients with achalasia shows fewer ganglion cells with a mononuclear inflammatory infiltrate. Circular muscle of the LES is thickened, but, microscopically, muscle cells are normal.

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