What is the efficacy of high-resolution manometry in the workup of esophageal motility disorders?

Updated: Dec 29, 2017
  • Author: Eric A Gaumnitz, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Salvador et al assessed high-resolution manometry (36-channel catheter, 1-cm sensor intervals) studies in 106 patients and 50 healthy controls and classified findings into abnormalities of the gastroesophageal barrier and of the esophageal body. [5] The findings were validated with endoscopic and radiographic comparisons.

The investigators demonstrated a significantly lower mean time for high-resolution manometry (8.1 mins) compared with a conventional method (24.4 mins; P< 0.0001). [5] The presence of a lower esophageal sphincter defect by high-resolution manometry was validated in 86.3% (44/51) of patients via radiography/endoscopy, and 80% (41/51) of patients had a positive pH study, endoscopic erosive esophagitis, or Barrett esophagus. [5]

Carlson et al have indicated that  esophageal pressure topography (EPT) may be the preferred assessment modality of esophageal motility over conventional line tracings (CLT). [11]  Six attending gastroenterologists and six gastroenterology fellows from 3 academic centers interpreted each of the 40 studies using both EPT and CLT formats: Among all raters, the odds of an incorrect exact esophageal motility diagnosis were 3.3 times higher with CLT than with EPT, and the odds of incorrect identification of a major motility disorder were 3.4 times higher with CLT than with EPT.


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