Which medications in the drug class Histamine-2 Receptor Antagonists are used in the treatment of Esophagitis?

Updated: May 28, 2020
  • Author: Deepika Devuni, MD; Chief Editor: BS Anand, MD  more...
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Answer

Histamine-2 Receptor Antagonists

These agents decrease gastric acid production by blocking histamine-2 (H2) receptors in gastric cells. Some authorities recommend using larger doses than those used for peptic ulcer disease.

Ranitidine hydrochloride (Zantac, Zantac 75, Zantac 150)

Ranitidine hydrochloride competitively inhibits histamine at the H2 receptor of gastric parietal cells, resulting in reduced gastric acid secretion, gastric volume, and hydrogen ion concentrations. As of April 1, 2020, ranitidine was withdrawn from the market due to an increasing number of products containing the contaminant known as N-Nitrosodimethylamine (NDMA), a probable carcinogen in humans. Moreover, nizatidine (Axid), another H2 receptor blocker, has also been withdrawn because of contamination with NDMA.. 

Cimetidine (Tagamet HB 200)

Cimetidine inhibits histamine at H2 receptors of gastric parietal cells, decreasing gastric acid secretion, gastric volume, and hydrogen ion concentrations.

Famotidine (Pepcid, Pepcid AC)

Famotidine competitively inhibits histamine at H2 receptors of gastric parietal cells, resulting in reduced gastric acid secretion, gastric volume, and hydrogen concentrations.


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