What is the pathophysiology of radiation and chemoradiation esophagitis?

Updated: May 28, 2020
  • Author: Deepika Devuni, MD; Chief Editor: BS Anand, MD  more...
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Answer

Radiation dose over 30 Gy to the mediastinum typically causes retrosternal burning and painful swallowing, which is usually mild and limited to the duration of therapy. [17]

  • A dose of 40 Gy causes mucosal redness and edema.
  • A dose of 50 Gy causes a higher incidence and severity of esophageal damage.
  • A dose of 60-70 Gy causes moderate-to-severe esophagitis with strictures, perforations, and fistulas.

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