What causes infectious esophagitis?

Updated: May 28, 2020
  • Author: Deepika Devuni, MD; Chief Editor: BS Anand, MD  more...
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Answer

Treatment of infectious esophagitis is directed at the underlying cause, as follows:

  • Fungal esophagitis – Topical, oral, or parenteral antifungals
  • HSV esophagitis – Acyclovir, foscarnet (for acyclovir-resistant cases), or famciclovir
  • CMV esophagitis – Ganciclovir and foscarnet
  • HIV esophagitis – Oral corticosteroids in conjunction with antiretroviral therapy
  • Varicella-zoster virus (VZV) esophagitis – Acyclovir, famciclovir, or foscarnet (for acyclovir-resistant cases)
  • Epstein-Barr virus (EBV) esophagitis – Acyclovir
  • Human papillomavirus (HPV) esophagitis – No treatment, in most cases; systemic interferon alfa, bleomycin, or etoposide
  • Tuberculous esophagitis – Standard antituberculous therapy
  • Bacterial esophagitis – Broad-spectrum beta-lactam antibiotics, usually with an aminoglycoside, adjusted as appropriate

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