What are the limitations of crossmatching?

Updated: Jan 22, 2019
  • Author: Ashok Tholpady, MD, MSc; Chief Editor: Jun Teruya, MD, DSc, FCAP  more...
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The following are limitations to crossmatching [6] :

  • Does not prevent delayed transfusion hemolytic reactions with transfusion of compatible blood if an antibody titer is not high enough to detect

  • Does not detect Rh incompatibility: Plasma from an Rh-negative recipient may not react with Rh-positive donor RBCs in the absence of anti-D antibodies

  • Does not detect minor ABO incompatibility (eg, group A donor blood given to group AB recipient)

  • Does not gurantee normal survival of the transfused red blood cells

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