What causes incompatibility results on an antiglobulin crossmatch test?

Updated: Jan 22, 2019
  • Author: Ashok Tholpady, MD, MSc; Chief Editor: Jun Teruya, MD, DSc, FCAP  more...
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The crossmatch incompatibility detected in antiglobulin crossmatch can be associated with the following conditions:

  • Presence of an alloantibody or alloantibodies to RBC-specific antigen(s) on the donor unit(s) that has/have not been identified, especially for antibodies that demonstrate dosage and donor RBCs from heterozygotes or donor RBCs carrying a low-incidence antigen
  • Presence of passively acquired anti-A and anti-B antibody

  • Presence of cold or warm-reactive autoantibody

  • Presence of antibody to an ingredient in the enhancement media or enhancement-dependent autoantibody

  • Positive direct antiglobulin test result of donor RBCs

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