What are the clinical indications for crossmatching blood?

Updated: Jan 22, 2019
  • Author: Ashok Tholpady, MD, MSc; Chief Editor: Jun Teruya, MD, DSc, FCAP  more...
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The crossmatch is routinely used as the final step of pretransfusion compatibility testing. It serves two purposes: (1) to serve as a final check of ABO compatibility between donor red blood cells (RBCs) and patient plasma or serum and (2) to detect clinically significant antibodies that may have been missed by the antibody screening test.

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