Which results on a direct antiglobulin test (DAT) are characteristic of drug-induced hemolysis?

Updated: Jun 25, 2020
  • Author: Julie Katz Karp, MD; Chief Editor: Jun Teruya, MD, DSc, FCAP  more...
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Drugs may cause a positive direct antiglobulin test result and/or immune-mediated hemolysis, with an incidence of approximately 1 in 1 million. [4]

Drugs can induce the formation of antibodies, either against the drug itself or against intrinsic RBC antigens or the RBC membrane. This may result in a positive direct antiglobulin test result, immune hemolysis, or both.

Drugs commonly implicated in this include penicillin, second- and third-generation cephalosporins, alpha-methyldopa, and procainamide, among others.

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