Which results on a direct antiglobulin test (DAT) are characteristic of hemolytic disease in the fetus and newborn?

Updated: Jun 25, 2020
  • Author: Julie Katz Karp, MD; Chief Editor: Jun Teruya, MD, DSc, FCAP  more...
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Hemolytic disease of the fetus and newborn is the destruction of fetal and newborn RBCs by maternal immunoglobulin G (IgG) alloantibodies that cross via the placenta into the fetal circulation. [4]

Maternal alloantibodies are specific for inherited paternal RBC antigens expressed by fetal RBCs.

Maternal alloantibodies bind to the corresponding antigen on fetal RBCs, resulting in a positive direct antiglobulin test result.

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