Which results on a direct antiglobulin test (DAT) are characteristic of hemolytic transfusion reactions?

Updated: Jun 25, 2020
  • Author: Julie Katz Karp, MD; Chief Editor: Jun Teruya, MD, DSc, FCAP  more...
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A positive direct antiglobulin test result may be the first indication of an immune response to a recent transfusion. [4]

The patient's developing antibodies will coat transfused RBCs bearing the corresponding antigen, resulting in a positive direct antiglobulin test result.

Antibodies appear within 7-10 days after a primary exposure or within 1-2 days of a secondary response.

Antibodies can shorten the survival of previously or subsequently transfused RBCs.

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