Which medications in the drug class Anticholinergic Agents are used in the treatment of Crohn Disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Anticholinergic Agents

Abdominal cramps may be reduced with anticholinergic agents such as propantheline, dicyclomine, or hyoscyamine. These drugs should not be used if there is the possibility of a bowel obstruction.

Dicyclomine (Bentyl)

Dicyclomine treats GI motility disturbances. It blocks the action of acetylcholine at parasympathetic sites in secretory glands, smooth muscle, and the central nervous system (CNS). Adverse effects are dose-dependent.

Hyoscyamine (Levsin, Levbid, Anaspaz, Symax, NuLev)

Hyoscyamine blocks the action of acetylcholine at parasympathetic sites in smooth muscle, secretory glands, and the CNS, thereby exerting antispasmodic effects. This agent decreases fecal urgency and pain.


Propantheline is a quaternary ammonium antimuscarinic agent with peripheral effects that are similar to those of atropine. It inhibits GI motility and decreases gastric acid secretion.

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