Which medications in the drug class Bile Acid Sequestrants are used in the treatment of Crohn Disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Bile Acid Sequestrants

Patients with terminal ileal disease may not absorb bile acids normally, which can lead to secretory diarrhea in the colon. These patients may benefit from bile acid sequestrants such as cholestyramine and colestipol.

Cholestyramine (Prevalite, Questran, Questran Light)

Cholestyramine is used for diarrhea associated with Crohn disease. It binds bile acids, thereby reducing damage to the intestinal mucosa. Cholestyramine also reduces the induction of colonic fluid secretion. It forms a nonabsorbable complex with bile acids in the intestine, thereby, in turn, inhibiting enterohepatic reuptake of intestinal bile salts.

Colestipol (Colestid)

Colestipol forms a soluble complex after binding to bile acid, increasing fecal loss of bile acid–bound low-density lipoprotein cholesterol.


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