Which medications in the drug class Antidiarrheals are used in the treatment of Crohn Disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Chronic diarrhea in Crohn disease responds well to antidiarrheal agents such as loperamide (2-4 mg), diphenoxylate with atropine (1 tablet), and tincture of opium (8-15 drops). Such agents may be administered up to 4 times daily, but they should not be given to patients with active colitis, because of the risk of developing toxic megacolon.

Loperamide (Imodium, Diamode)

Loperamide, which is available over the counter, acts on intestinal muscles to inhibit peristalsis and to slow intestinal motility. It prolongs the movement of electrolytes and fluid through the bowel and increases the viscosity and loss of fluids and electrolytes. Loperamide improves stool frequency and consistency, reduces abdominal pain and fecal urgency, and may exacerbate constipation.

Diphenoxylate-atropine (Lomotil)

The combination of diphenoxylate with atropine consists of 2.5 mg of diphenoxylate, which is a constipating meperidine congener, and 0.025 mg of atropine to discourage abuse. The preparation inhibits excessive gastrointestinal (GI) propulsion and motility, but it may exacerbate constipation.

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