Which medications in the drug class Antibiotics are used in the treatment of Crohn Disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Antibiotics

Antibiotics are used in the treatment of mild-to-moderate, fistulizing, and perianal disease. Antibiotics may change the microbial flora of the intestine and have a potential effect on the cell-mediated immune system.

Metronidazole (Flagyl)

Metronidazole is an imidazole ring–based antibiotic that is active against various anaerobic bacteria and protozoa. It is sometimes used in combination with other antimicrobial agents (except for Clostridium difficile enterocolitis). Metronidazole also possesses immunosuppressive and anti-inflammatory properties.

Ciprofloxacin (Cipro)

A fluoroquinolone, ciprofloxacin has activity against pseudomonads, streptococci, methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, and most gram-negative organisms, but it has no activity against anaerobes. Ciprofloxacin inhibits bacterial DNA synthesis and, consequently, growth.


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