Is low-dose oral naltrexone effective for treatment of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Evidence supporting the efficacy of low-dose oral naltrexone for the treatment of Crohn disease is limited; the 2 main studies had small patient cohorts and short duration of follow-up. Thus, at present, there is no clear indication for the use of low-dose oral naltrexone for Crohn disease. However, a small subpopulation may benefit from treatment. Further, larger studies may be warranted.


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