What is the role of T suis in the treatment of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Early studies have suggested the use of the helminth Trichuris suis for the treatment of Crohn disease. This suggestion is based on the observation that the disease is common in highly industrialized Western countries, where helminths are rare, but uncommon in less developed areas of the world, where most people carry the worms. It is believed that helminths diminish immune responsiveness in naturally colonized humans and reduce inflammation in experimental colitis. Studies evaluating the use of T suis eggs for this purpose are under way.


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