What is the dosing for mycophenolate mofetil in the treatment of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Mycophenolate mofetil has been used in the short- and long-term treatment of difficult IBD. This agent inhibits a de novo pathway of purine synthesis in lymphocytes, leading to intracellular depletion of guanosine monophosphate and resulting in the suppression of cytotoxic T cells and the formation of antibodies by activated B cells. A dose of 500 mg twice daily in 2 divided doses is well tolerated by patients and can be used to reduce the steroid dose. [2, 85]


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