Is tacrolimus an effective treatment for Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Tacrolimus may be effective in treating Crohn disease. A systematic review of the role of tacrolimus found remission rates of 44.3% for patients with luminal Crohn disease and 28.6% for patients with perianal disease when this agent was used systemically. [119] The review noted that in studies of topical use of tacrolimus, 35.7% of patients achieved remission and 28.6% a partial response. [119]

Side effects included tremor, paresthesia, and headache; recurrent nephrotoxicity occurred in 16% of patients. [119] Although this review appears to support the use of tacrolimus, the investigators noted that randomized controlled trials are needed.

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