Are there restrictions on the use of natalizumab for the treatment of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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This drug was initially taken off of the market in 2005 as a result of reported cases of progressive multifocal leukoencephalopathy (PML) in patients with multiple sclerosis [2] ; it was then reintroduced into the market with restrictions for the indication of refractory multiple sclerosis in 2006 and Crohn disease in 2008.

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