What are the possible adverse effects of infliximab in the treatment of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Important adverse effects include the development of a lupus like syndrome, multiple sclerosis, psoriasiform rash, and opportunistic or fungal infections (eg, Pneumocystis jiroveci pneumonia or histoplasmosis). Anti–double-stranded DNA is not always associated with clinical lupus. An added benefit of infliximab treatment is the potential ability to taper steroids, which will decrease further adverse effects. [96, 97]


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