Is infliximab effective in the treatment of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

In one study, nearly 65% of refractory cases of Crohn disease responded well to treatment with infliximab (5 mg/kg), and one third went into complete remission. [95] Patients who relapsed after the initial response responded again to further infusions.

Infliximab is also effective in patients who have refractory perianal and enterocutaneous fistulae. Current clinical practice is to give 5 mg/kg IV at 0 weeks, 2 weeks, and 6 weeks, followed by maintenance IV infusions every 8 weeks. On average, the effect lasts for 12 weeks.


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