What is the role of methotrexate in inducing and maintaining remission in Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Methotrexate is effective in inducing and maintaining remission in Crohn disease in adults; it has also been shown to be effective and well tolerated for maintenance of remission in children. [90] The onset of action is shorter for methotrexate than for 6-MP, and the once-weekly dosing is sometimes preferred. Whether oral therapy is as effective as parenteral therapy is unclear.

A systemic review of the efficacy of biologic therapies in IBD confirmed that placebo is inferior to anti−TNF-α antibodies and natalizumab in inducing remission of active Crohn disease. [91]


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