What is the role of thiopurine methyltransferase (TPMT) activity measurement in the treatment of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Before the initiation of therapy, thiopurine methyltransferase (TPMT) activity should be measured to identify patients predisposed to altered drug metabolism, which increases the risk of early leukopenia. Measurement of 6-thioguanine nucleotide (6-TG) metabolites is helpful in assessing compliance and adjusting dosing.


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