What are the indications for corticosteroid therapy in Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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A short course of corticosteroid therapy is indicated in patients with severe systemic symptoms (eg, fever, nausea, or weight loss) and in those whose condition does not respond to anti-inflammatory agents. Prednisone is generally helpful in acute inflammation without signs of obvious infection. In patients with a tender, palpable mass, the possibility of an underlying abscess should be excluded before steroids are started. Adding antibiotics such as ciprofloxacin or metronidazole is always beneficial if coexisting infection exists.

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