What are causes of diarrhea in Crohn disease and how is it treated?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Diarrhea may develop as a result of active disease. Other possible causes include acute infection (ie, C difficile), bacterial overgrowth, loss of ileocecal valve, short bowel syndrome, lactase deficiency, concomitant celiac disease, and functional bowel syndrome. Chronic diarrhea in Crohn disease responds well to antidiarrheal agents such as loperamide, bile acid binders (for bile acid diarrhea), diphenoxylate with atropine, and tincture of opium. Such agents should be considered with care in active colitis because of the risk of toxic megacolon.


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