How is upper GI tract Crohn disease typically characterized?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Upper GI tract Crohn disease may be more challenging to diagnose. The histologic picture of gastric Crohn disease is typically described as focally enhancing gastritis in the setting of negative H pylori or other infections. Esophageal or duodenal biopsies in Crohn disease may reveal villous architectural changes with moderate inflammation. Granulomas generally are not identified, but when they are present, they provide substantial corroborative evidence for the diagnosis.

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