In addition to ASCAs and p-ANCA, which serologic markers may suggest Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Additional serologic markers, such as Escherichia coli anti-ompC (outer membrane porin C), can be found in more than 50% of Crohn disease cases and in only a small percentage of ulcerative colitis cases. Pseudomonas fluorescens (anti-12) may be found in more than 50% of Crohn disease cases and in only 10% of ulcerative colitis cases. Flagellinlike antigen (anti-Cbir1) is associated independently with small bowel, intestinal penetrating, and fibrostenosing disease. These tests further increase sensitivity and diagnostic value.


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