What are the limitations of serologic testing to differentiate between ulcerative colitis and Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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It should be noted that both tests are recommended only as an adjunct to the clinical diagnosis; the results are not specific and have been found to be positive in other bowel diseases. Patients with Crohn disease whose condition is ASCA-positive have a higher rate of surgery and require surgery earlier in the course of the disease, independent of the area of involvement. [1, 2, 6]

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