Has a risk model for complications of Crohn disease based on levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) been validated?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

A risk-stratification model based on levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which are significantly associated with complications of Crohn disease, could reduce the use of computed tomography (CT) scans in patients reporting to the emergency department by 43%, while missing only 0.8% of emergencies, according to a retrospective analysis of 613 adult patients. [60] Researchers used logistic regression to model associations between these laboratory values and perforation, abscess, or other serious complications. Further validation studies of the models need to be performed.


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