Does primary sclerosing cholangitis increase the risk of developing Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Primary sclerosing cholangitis has an established strong association with IBD, particularly ulcerative colitis. About 5-10% of patients with primary sclerosing cholangitis have Crohn disease, but only 2% of Crohn disease patients develop primary sclerosing cholangitis. There is a 2:1 male prevalence for the disorder.

The clinical course of primary sclerosing cholangitis does not parallel bowel disease, and this condition can develop in the years before or after the development of GI symptoms. Patients with this disease may require transplantation if cirrhosis develops or if severe recurrent cholangitis occurs.


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