What are the symptoms of primary sclerosing cholangitis in patients with Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Primary sclerosing cholangitis is a progressive chronic liver condition of unknown etiology that increases the risk for cholangiocarcinoma and colorectal cancer in patients with IBD. Patients can be asymptomatic with mild elevations of transaminase and alkaline phosphatase, or they may present with advanced findings of cholangitis and jaundice. Magnetic resonance cholangiopancreatography (MRCP) or endoscopic retrograde cholangiopancreatography (ERCP) typically reveals strictures of medium and large intrahepatic and extrahepatic bile ducts.

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