What are the urologic extraintestinal manifestations (EIMs) of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Urologic EIMs include nephrolithiasis, hydronephrosis, and enterovesical fistulae. The incidence of gallstones and kidney stones is increased in Crohn disease because of malabsorption of fat and bile salts. Nephrolithiasis occurs in fewer than 5% of children with Crohn disease, usually as a result of the fat malabsorption that occurs with small bowel Crohn disease. Dietary calcium binds to malabsorbed fatty acids in the colonic lumen; therefore, free oxalate is absorbed. The absorption of free oxalate results in hyperoxaluria and oxalate stones.


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