What is the cumulative risk of colon cancer in Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

A meta-analysis revealed that the cumulative risk of colon cancer in Crohn disease approaches 3% at 10 years and 8% at 30 years. [47] It is widely known that individuals diagnosed at a younger age have a long disease duration (> 8 years), and that those with concomitant primary sclerosing cholangitis are at an increased risk for colorectal cancer.

The association of IBD with increased risk of colon cancer has led to North American consensus statements that recommend regular surveillance with colonoscopy every 1-3 years for those with either ulcerative colitis or colonic Crohn disease who have a disease duration longer than 8 years.

However, subsequent studies yielded different findings regarding the risk for colorectal cancer in people with Crohn disease. A population-based study did not show any temporal trends in colorectal cancer for Crohn disease, nor did it find an increased risk of such cancer in patients with this condition as compared with the general population. [48] In contrast, a health maintenance organization (HMO) study from Northern California found a 60% increased relative risk of colorectal cancer, which did not change over a 12-year period. [49]


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