Is colon cancer a possible complication of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Colonic malignancy is a clinically significant complication of Crohn disease with colonic involvement. Chronic inflammation is the conjectured etiology for the development of dysplasia followed by cancer. Most cases of colorectal cancer develop from early histologic lesions referred to as low-grade dysplasia (LGD) or dysplasia-associated lesion or mass (DALM). Sporadic adenomas can also progress to colon cancer. These are premalignant or precancerous lesions that progress to cancer via a pathway of inflammation and genetic mutations.

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