What is the initial presentation of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Low-grade fever, prolonged diarrhea with abdominal pain, weight loss, and generalized fatigability are usually reported. Crampy or steady right lower quadrant or periumbilical pain may develop; the pain precedes and may be partially relieved by defecation. Diarrhea is usually not grossly bloody and is often intermittent. If the colon is involved, patients may report diffuse abdominal pain accompanied by mucus, blood, and pus in the stool. [1, 2, 11, 43, 44]

It is important to note that colonic Crohn disease may be clinically indistinguishable from ulcerative colitis, with symptoms of bloody mucopurulent diarrhea, cramping abdominal pain, and urgency to defecate.

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