Are specific genes prognostic factors in Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Genetic studies are yielding evidence associating particular variants of the CARD15 gene with the prognosis of Crohn disease. [10] Specific CARD15 mutations have been linked with the intestinal site of the disease (eg, ileal site), and certain variants have been found to be associated with the propensity for developing strictures and with an early onset of disease. [10] In the future, these variants may be helpful in predicting the course of the disease in affected individuals.


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