Do environmental factors such as smoking, high-fat diet, and measles vaccine increase the risk of developing Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Environmental influences such as tobacco use seem to have an effect on Crohn disease. Smoking has been shown to double the risk of Crohn disease, whereas the risk of developing ulcerative colitis is lower in people who smoke than in those who have never smoked or in those who stopped smoking before their diagnosis. [11, 27]

It has been suggested that a diet high in fatty foods may increase the risk of Crohn disease. [28] Concerns about the measles vaccine and the development of the disease have proved to be unfounded. [29] Although appendectomy has been suggested to be protective in ulcerative colitis, it is not a protective factor in Crohn disease. [30]

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