What are the roles of the genes CCR6, IL12B, STAT3, JAK2, LRRK2, CDKAL1, and PTPN22 in the etiology of Crohn disease?

Updated: Jul 26, 2019
  • Author: Leyla J Ghazi, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

In a meta-analysis of 3 GWASs, 526 SNPs from 74 distinct genomic loci were found. [18] In addition to loci that have been previously discussed, 21 new loci were found that were associated with an increased risk of developing Crohn disease. Among the new loci were some very interesting implications, including the genes CCR6, IL12B, STAT3, JAK2, LRRK2, CDKAL1, and PTPN22. [18] Most of these genes are involved in signal transduction in certain immune function, as well as genes involved more directly with immune function.


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