Which histologic findings are characteristic of choledochal cysts?

Updated: Jul 01, 2020
  • Author: Emily Tommolino, MD; Chief Editor: BS Anand, MD  more...
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Answer

Evidence of chronic inflammation is typically observed in the cyst wall. The cyst wall is thin, fibrous, and frequently devoid of a true epithelial surface, although it can be lined by a low columnar epithelium. Note that infants can develop complete obstruction of the distal common bile duct secondary to acute and chronic inflammatory changes. In the liver, ductal fibrosis and portal edema may be present. Changes consistent with biliary cirrhosis may be observed in adults with long-standing disease. The most feared histologic abnormality is the presence of cholangiocarcinoma.


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