What is the role of endotoxin in the pathogenesis of cholecystitis?

Updated: May 20, 2021
  • Author: Alan A Bloom, MD; Chief Editor: BS Anand, MD  more...
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Answer

A study by Cullen et al demonstrated the ability of endotoxins to cause necrosis, hemorrhage, areas of fibrin deposition, and extensive mucosal loss, consistent with an acute ischemic insult. [5] Endotoxins also abolish the contractile response to CCK, leading to gallbladder stasis.


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