What is the role of antigliadin and immunoglobulin A (IgA) antibody testing in the diagnosis of celiac disease?

Updated: Oct 10, 2018
  • Author: Stephan U Goebel, MD; Chief Editor: BS Anand, MD  more...
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Answer

The presence of serum IgA antibody to endomysium in untreated celiac disease has higher sensitivity and higher specificity than antigliadin antibodies. However, serum IgA antiendomysial antibody often becomes undetectable after 6-12 months of gluten withdrawal. Persistently elevated IgA endomysial and tissue transglutaminase antibodies for 12 months usually indicate poor compliance with a gliadin-free diet.


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