How is the diagnosis of celiac disease (sprue) confirmed?

Updated: Nov 29, 2019
  • Author: Stephan U Goebel, MD; Chief Editor: BS Anand, MD  more...
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The diagnosis of celiac disease is confirmed via histopathologic evaluation of duodenal biopsy specimens. [7]  Corroboration comprises evidence of small intestinal villous atrophy in the presence of celiac autoantibodies and/or an unequivoval response to a gluten-free diet. [8] Controversy exists regarding making the diagnosis without biopsy in specific cases, particularly in the pediatric population. [7]

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