What are the extraintestinal symptoms of celiac disease (sprue)?

Updated: Nov 29, 2019
  • Author: Stephan U Goebel, MD; Chief Editor: BS Anand, MD  more...
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Extraintestinal symptoms may include the following:

  • Anemia - 10-15% of patients

  • Osteopenia and osteoporosis - 1-34% of patients

  • Neurologic symptoms - 8-14% of patients; include motor weakness, paresthesias with sensory loss, and ataxia; seizures may develop [1]

  • Skin disorders - 10-20% of patients; including dermatitis herpetiformis, a condition with pruritic, papulovesicular skin lesions involving the extensor surfaces of the extremities, trunk, buttocks, scalp, and neck

  • Hormonal disorders - Including amenorrhea, delayed menarche, and infertility in women and impotence and infertility in men

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