Which medications in the drug class Bile acids are used in the treatment of Primary Biliary Cholangitis (Primary Biliary Cirrhosis)?

Updated: Nov 08, 2017
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

Bile acids

UDCA is the major medication used to slow the progression of the disease. Patients with early disease have clinical, biochemical, and histologic improvement. Reports suggest that UDCA delays the need for transplantation and delays death. The efficacy of this medication in late stages (ie, cirrhosis) is questionable.

Ursodiol (Actigall)

Displaces endogenous bile acids from enterohepatic circulation, stabilizes hepatocellular membranes, and reduces the abnormal expression of HLA class I and II molecules on hepatocytes.


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