Which medications in the drug class Antihistamines are used in the treatment of Primary Biliary Cholangitis (Primary Biliary Cirrhosis)?

Updated: Nov 08, 2017
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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These agents are the first line of medication for patients with mild-to-moderate pruritus. Use caution in patients with cirrhosis and signs of encephalopathy because antihistamines can further depress brain function.

Hydroxyzine hydrochloride (Vistaril, Atarax)

Antagonizes H1 receptors in periphery. May suppress histamine activity in subcortical region of CNS.

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