Which medications are used in the treatment of primary biliary cholangitis (PBC)?

Updated: Nov 08, 2017
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

Immunosuppressive agents inhibit immune reactions that mediate the progression of the disease.

Methotrexate: Results of various trials suggest improvement in biochemical and histologic findings after treatment.

Corticosteroids may alleviate symptoms and improve biochemical and histologic findings. Corticosteroid-induced osteoporosis is of great concern. The dangers of using bisphosphonates requires further study. [14]

Cyclosporine has some therapeutic potential.

Colchicine has been used with limited effect.


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