Which histologic findings are characteristic of primary biliary cholangitis (PBC)?

Updated: Nov 08, 2017
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

Primary biliary cholangitis is characterized by chronic, nonsuppurative, destructive cholangitis of the small interlobular bile ducts with a diameter of 40-80 mm. Early lesions signal damage of the basement membrane of the bile ducts and reactive hyperplasia of the epithelial lining. Lymphocytic and plasma cell infiltration, with eosinophilic condensation in the portal tracts, is another feature. Epithelioid aggregates or granulomas may be found around the bile ducts. Fibrosis and cirrhosis develop later.


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