What is the mortality rate for primary biliary cholangitis (PBC)?

Updated: Nov 08, 2017
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

For asymptomatic patients with antimitochondrial antibody (AMA)–positive findings, a normal biochemical liver profile, and histologic features that are compatible with primary biliary cholangitis, the progression of the disease is relatively slow; however, the patient life expectancy is not identical to that of the general population. Of these patients, 40-67% develop symptomatic disease in approximately 5-7 years. Once they develop symptoms (mainly cholestasis) and remain untreated, the median patient survival duration ranges from 5.5-12 years. Generally, the median survival duration from the time of diagnosis is 7.5 years for patients who are symptomatic and 16 years for patients who are asymptomatic.

Significant changes in the mortality rate have been noticed since the early 1980s with an increase in the age of death. This might be a consequence of treatment. [6]


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