Which patients are at highest risk for primary biliary cholangitis (PBC)?

Updated: Nov 08, 2017
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

Primary biliary cholangitis is most frequently a disease of women and occurs between the fourth and sixth decades of life. The symptoms may strongly affect patients' quality of life and may induce incapacitation. Various therapeutic approaches have been implemented with variable results; in selected candidates, liver transplantation is the only treatment option for the terminal stages of the disease. After the procedure, the disease has a relatively high recurrence rate despite immunosuppressive therapy.

The image below demonstrates the histologic appearance of stage 2 primary biliary cholangitis.

This histologic picture is compatible with stage 2 This histologic picture is compatible with stage 2 primary biliary cholangitis.

For patient education resources, see the Digestive Disorders Center and the Infections Center, as well as Cirrhosis.


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